Read about targocid 400mg injection uses, side effects, dosage, price, composition and substitutes. Pkpd target attainment with ceftolozanetazobactam using. Fever, chills, allergic reactions, gi disturbances, headache, dizziness, redman syndrome, disturbances in liver enzymes, renal impairment. Targocid 400 mg injection is used to treat serious bacterial infections. Other trade names include ticocin marketed by ciplaindia. Teicoplanin is marketed by sanofiaventis under the trade name targocid. During continuous renal replacement therapy usually a normal or near normal dose might be advisable. Targocid 400mg summary of product characteristics smpc. Monte carlo simulations were conducted for patients with arc and normal renal function, mild renal impairment, moderate renal impairment, or severe renal impairment, and for 5000 patients with esrd. Dosing guidelines book school of medicine university of. Targocid 200mg injection is an antibiotic that is used for the treatment of bacterial infections which sometimes occurs in the blood or joint or bone. Home delivery for targocid in your city medicine india. Drug targocid 200mg1vial 1vial injection teicoplanin. Patients may require 15 mgkg given 3 times a week us hhs, nih, hrsa, and us cdc recommendations.
Abacavir abacavir lamivudine abacavir lamivudine zidovudine acarbose acebutolol acetaminophen acetazolamide acetohexamide acetohydroxamic acid acetylsalicylic acid aspirin acrivastine acyclovir adefovir adenosine albuterol inhaled albuterol oral alfentanil alfentanil allopurinol alprazolam alteplase tissuetype plasminogen activator. Following intravenous and intramuscular administration, teicoplanin is widely distributed in body tissues. Renal drug handbook 3rd edition general intensive care unit. Acute effects of dipyrone on renal function in patients. In the most critical patients, the continuous infusion of antiinfective drugs might allow for higher and more efficacious dosing without an increased risk of toxicity meropenem, piperacillin, oxacillin, vancomycin, acyclovir. Teicoplanin is nephrotoxic in animals, although at much higher doses than those used in humans. The incidence of hepatic dysfunction, renal impairment and thrombocytopenia is 14. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
This guideline may be varied, withdrawn or replaced at any time. Trulicity dulaglutide dosing, indications, interactions. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease. The information on dosage adjustments in renal impairment given in this book is based on.
Prescribing principles for patients with chronic kidney disease ensure safe and effective prescribing for these patients, whether seen as part of the everyday routine or the occasional encounter. Simplified dosing regimens of teicoplanin for patient groups. Targocid 400 mg injection uses, side effects, price, dosage. Antimicrobial dosing in renal impairment chw date of publishing. This page includes the following topics and synonyms.
By continuing to browse this site you are agreeing to our use of cookies. Loading dose single iv or im injection of 400mg on first day. The relative behavior of the six major components was only slightly affected by renal failure. How to prescribe safely, rationally and effectively in ckd when prescribing for patients with ckd, many considerations have to be made. Oral teicoplanin has been demonstrated to be effective in the treatment of pseudomembranous colitis and clostridium difficileassociated diarrhoea, with comparable efficacy with vancomycin. By using a highly specific chromatographic technique, the effect of renal failure on the pharmacokinetics of the six main components of teicoplanin, taken individually or as a whole, was assessed for over 120 h after administration of a 3mgkg intravenous dose to healthy volunteers group 1, n 6 and to noninfected patients with moderate group 2, n 6 or severe group 3, n 7. Drug dosing in chronic kidney disease, medication dosing in chronic kidney disease, renal dosing, antibiotic dose adjustments in impaired renal function, antihypertensive dose adjustments in impaired renal function, analgesic dose adjustments in impaired renal function, ace inhibitor and angiotensin receptor blocker adjustments in impaired renal function, end stage renal disease medication dosing, drug dosing in esrd. Each monograph contains stability data, administration guidelines, and methods of preparation. Following intravenous and intramuscular administration, targocid is widely distributed in body tissues.
Adult or elderly patients with normal renal function. This medication is given when other antibiotics fail to fully eliminate the bacteria or in cases when other patients are allergic to other antibiotics. The oral dose recommendation for teicoplanin is 100400 mg by mouth every 12 hours for 10 days. As the field moves forward so also do the therapeutic opportunities, and pitfalls. Medicine india is just a publishing medium for medicine related information and does not provide services or sales of medicines including targocid. In infants, the loading dose of teicoplanin is 16 mgkg administered intravenously. Feb 27, 2020 detailed metoclopramide dosage information for adults and children.
Targocid 200mg injection uses, side effects, substitutes. Pdf dosage des antibiotiques en cas dinsuffisance renale. Although a number of published tables that provide dosing gu. Simulated dosing regimens were based on approved doses for each renal. The content on this site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Dosing of antiretroviral drugs in adults with chronic kidney. Adults and elderly patients with impaired renal function.
Prescribing principles for patients with chronic kidney disease. Drug dosing in renal insufficiency needs to be individualized whenever possible to optimize therapeutic outcomes and to minimize toxicity. Analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. Population pharmacokinetics of total and unbound teicoplanin. Annex iii summary of product characteristics, labelling. The purpose of this study was i to determine the optimal dosage of teicoplanin for each patient group stratified by renal function and weight based on a population pharmacokinetic model and observed distribution of patient characteristics and ii to develop new simplified dosing regimens designed to achieve 1530. This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. Evolution within the field of dialysis and advances in surgical procedures providing for superior access for shunt placement have made it possible to treat patients with endstage renal disease with. Bennetts drug prescribing in renal failure has been the best pocket book for drug prescribing in patients with renal insufficiency and dialysis since the first edition in 1987. Aug 28, 2019 targocid 400mg summary of product characteristics smpc by sanofi.
Drug dosing in renal disease matthew p doogue, 1,2 thomas m polasek 1. Maraviroc tablets dosage adjustment for patients with mild or moderate chronic kidney disease does not appear necessary crcl renal impairment or endstage renal disease who are taking a potent cyp3a inhibitor or inducer. The renal drug handbook the st georges hospital, adult critical. Drug dosing in these patients often proves to be a difficult task.
The authors make no claims of the accuracy of the information contained herein. Adults and elderly patients with impaired renal function dose adjustment is not required until the fourth day of treatment, at which time dosing should be adjusted to maintain a serum trough concentration of at least 10 mgl when measured by hplc, or at least 15 mgl when measured by fpia method. Teicoplanin does not show crossresistance with other classes of antibiotics. The ultimate prescribing guide for renal practitioners, 4th edition ashley, the renal drug handbook. It is slowly eliminated with a plasma halflife of 70 to 100 hours. Consequently, the dosage regimen adjustment could be based on the. Targocid 400mg powder for solution for injectioninfusion. Recommendation for the harmonisation of spcs regarding dosing ec decision september 20 the dose and duration of treatment should be adjusted according to the underlying type and severity of infection and clinical response of the patient, and patient factors such as age and renal function.
Intravenous iv preparation and infusion guidelines globalrph. Do not use egfr estimates available on pas for drug dosing purposes see 2006 article from hospital pharmacist. Targocid 200mg1vial 1vial injection teicoplanin drug information. Therefore, teicoplanin can be used in cases of osteomyelitis, septic arthritis and septicaemia. Sep 05, 2015 population pharmacokinetics and dosing optimization of teicoplanin in children with malignant haematological disease. The lower renal than total cl observed suggests there may be some nonrenal cl of teicoplanin, depending on renal function, probably through biliary secretion. Drug dosing in renal insufficiency talbert 1994 the. Teicoplanin has been approved for the treatment of serious staphylococcal or streptococcal infections which cannot be treated satisfactorily with less toxic antibiotics. Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in. Patients with chronic kidney disease ckd are at highrisk for adverse drug reactions and drugdrug interactions. The fifth edition of 2007 has been significantly expanded by dosage tables for children. Includes dosages for gastroesophageal reflux disease, gastroparesis, nauseavomiting chemotherapy induced and more.
Population pharmacokinetics and dosing optimization of. The renal drug handbook has developed into an essential resource for nephrologists, specialist nurses and pharmacists engaged in the care of these patients. Twice daily dosing is advised with reduced doses for patients with renal impairment. Arc and endstage renal disease esrd with hemodialysis.
The information on dosage adjustments in renal impairment given in this book is based on cockcroftgault creatinine clearance and not egfr, since the majority. Teicoplanin mechanism, indication, contraindications, dosing. Dosing in chronic kidney disease and hemodialysis references. Dosing recommendations are based on creatinine clearance calculated using the cockcroftgault equation. The recommended dose is 100200 mg administered orally twice a day for 7 to 14 days. Targocid does not show crossresistance with other classes of antibiotics. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes.
No dose adjustment is required, unless there is renal impairment see below. Targocid is indicated in adults and in children from birth for the parenteral treatment of the following infections see sections 4. Dose adjustment for renal impairment cockcroftgault crcl estimates using the creatinine clearance calculator should be used for drug dosing rather than the automated mdrd egfr produced by the clinical chemistry laboratory available on notis. Maintenance dose single im or iv injection of 200mg daily.
840 1316 1130 1380 252 303 927 1224 159 360 1254 420 443 898 334 487 117 1404 83 675 1169 773 1327 1489 452 95 1262 1178 1126 398